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Dr. Nineteen PoreXsome ReadyRN Exosome Ampoule: The Anti-Aging Ampoule with PDRN and Retinol

Updated on November 3, 2026·3 min read
Dr. Nineteen PoreXsome ReadyRN Exosome Ampoule: The Anti-Aging Ampoule with PDRN and Retinol

PDRN is the anti-aging active everyone is talking about in Korea. Combined with retinol, it gives us the Dr. Nineteen PoreXsome ReadyRN Exosome Ampoule: an intensive treatment for skin losing firmness and density. Here is how to use it effectively.

What is the Dr. Nineteen PoreXsome Ampoule for?

It is a concentrated anti-aging ampoule that targets several signs at once: loss of firmness, fine lines, enlarged pores, and tired-looking skin. It relies on two complementary actives.

On one hand, PDRN (polydeoxyribonucleotide), a highly popular active in Korean dermatology for its ability to revitalize skin and support its renewal. Dr. Nineteen boasts 750,000 ppm of Hyper PDRN™. On the other hand, retinol, the gold standard for smoothing wrinkles and refining skin texture. Together, they help skin appear smoother, denser, and plumper.

Key actives

  • Hyper PDRN™: revitalizes and supports skin density.
  • Retinol: smooths the appearance of wrinkles and tightens pores.
  • Exosomes: boost the action of the actives, according to the brand.

Who is it for?

It is designed for skin showing:

  • the first signs of aging and fine lines;
  • a loss of firmness and elasticity;
  • visible pores that become more pronounced over time;
  • tired-looking skin that lacks density.

Like all retinol treatments, it is not recommended during pregnancy or breastfeeding: consult a healthcare professional.

When to use it?

In the evening only, after toner. Retinol makes skin more sensitive to the sun: SPF the next morning is non-negotiable. Start with 2 evenings a week, then gradually increase according to your skin's tolerance.

How to use it?

  1. Cleanse your skin and apply your toner.
  2. Place 2 to 3 drops in your hand.
  3. Apply to the entire face, avoiding the eye and lip areas.
  4. Finish with a repairing cream.
  5. In the morning, apply SPF50.

Clow's tip: during the first few weeks, slight dryness may occur. This is the retinol adjustment phase: space out applications and boost hydration rather than stopping.

What to pair it with?

Pair it with a barrier cream such as the Aestura Atobarrier 365 Cream or the Centellian24 Madeca Cream Time Reverse. On retinol-free evenings, focus on hydration with the Torriden DIVE-IN serum. Do not use another retinoid or exfoliant on the same evening.

Frequently asked questions

At what age should I use it?

From the first signs of aging, generally from your thirties on, for prevention or correction.

Can it be paired with vitamin C?

Yes, but not at the same time: vitamin C in the morning, this ampoule in the evening.

When will I see results?

Skin appears plumper quickly. For wrinkles and firmness, allow 6 to 8 weeks of regular use.

Where can I find the Dr. Nineteen PoreXsome ReadyRN Exosome Ampoule?

You can find the Dr. Nineteen PoreXsome ReadyRN Exosome Ampoule on clowskincare.com for €54.95. All our skincare products are authentic, sourced in Korea, and selected by Laura & Coralie in Brussels. Express delivery in 1 to 2 days and free samples with purchases of €39 or more.

Still unsure? Take our 2-minute skin quiz to find out if this treatment has a place in your routine.

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